TFAP4 regulates the progression of liver fibrosis through the STING signaling pathway

作者: Chenyang Han, Jin Wang, Xiaohong Zhou, Wenyan Li, Yi Yang, Caiqun Zhang, Chenxi Cao
杂志: International Immunopharmacology
出版日期: 2025 Jan 18

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摘要

To investigate the mechanism by which the transcription factor TFAP4 promotes the progression of liver fibrosis through the STING signaling pathway. The expression of STING and TFAP4 in liver fibrosis mouse tissue was upregulated, AAV8-TFAP4 promoted the activation of the STING signaling pathway, and promoted the progression of liver fibrosis and tissue inflammation. In STING-KO mice, AAV8-TFAP4 could not further increase the level of liver fibrosis and tissue inflammation. Luciferase reporter gene experiments showed that there is an interactive relationship between TFAP4 and STING.TFAP4 can act as a transcription factor for STING, promote the activation of the STING signaling pathway, thereby exacerbating the progression of liver fibrosis and tissue inflammation in mice.

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