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Genome-Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle-Mediated siRNA Delivery
Author:
Wenhan Wang, Kangfu Chen, and Zongjie Wang
Journal: Advanced Science
Doi: https://www.doi.org/10.1002/advs.202517617
2025/12/7 -
Development of a high-affinity anti-ROR1 variable region for broad anti-cancer immunotherapy
Author:
Joshua K.M. Wong, Pui Yeng Lam, Elaina Coleborn, Jiya Jose, Louisa Alim , Cui Tu, Magdalena Antczak, Bettina Dietmair, Arghavan Golbaz Hagh, Lucia Noronha, Seth W. Cheetham, John Hooper, Paul A. Beavis, Delphine Merino, Jean Berthelet, Lauren G. Aoude, Amy E. McCart-Reed, Sunil Lakhani, Peter T. Simpson, Gustavo R. Rossi, Fernando Souza-Fonseca-Guimaraes
Journal: Molecular Therapy
Doi: https://www.doi.org/10.1016/j.ymthe.2025.11.021
2025/12/2 -
An RNA interference therapeutic potentially achieves functional cure of chronic hepatitis B virus infection
Author:
Ze-Ao Huang, Yang Yang, Shuo Yang, Guang-Shen Ji, Rui Fu, Zhi-Kang Tian, Yu-Cheng Wu & Geng-Shen Song
Journal: Nature Communications
Doi: https://www.doi.org/10.1038/s41467-025-66876-5
2025/12/1 -
BST2 impairs Schwann cell function to accelerate age-related hearing loss and serves as a novel serum biomarker
Author:
Mengxiao Liu, Huan Cao, Qi Li, Huan Yin, Jiantao Wang, Tao Liu, Lei Zhao, Jianwang Yang, Miaomiao An, Yanan Li, Chen Wang & Baoshan Wang
Journal: Acta Oto-Laryngologica
Doi: https://www.doi.org/10.1080/00016489.2025.2591707
2025/11/30 -
Activating PPARα in macrophages attenuates arterial remodeling via inhibiting YAP nuclear localization
Author:
Xinxin Lin, Xiaocong Liu, Jinglin shi, Tuohong Sun, Ting Feng, Benrui Sun, Hongbin Liang, Qiuxia Zhang, Guojun Chen, Siyu Chen, Alex Pui-Wai Lee, Shenjian Luo, Jiancheng Xiu, Xinlu Zhang
Journal: Biochemical Pharmacology
Doi: https://www.doi.org/10.1016/j.bcp.2025.117566
2025/11/28 -
Single-cell and bulk transcriptome analyses revealed the role of macrophage cholesterol metabolism in atherosclerosis
Author:
Jiaxing Ke, Shuling Chen, Lingjia Li, Chenxin Liao, Feng Peng, Dajun Chai & Jinxiu Lin
Journal: Lipids in Health and Disease
Doi: https://www.doi.org/10.1186/s12944-025-02773-6
2025/11/26 -
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity
Author:
Samuel J Resnick, Seema Qamar, Pushya Krishna, Vladislav Korobeynikov, Hannes Ausserwoger, Alyssa Miller, Pietro Esposito, Juan A Varela, Jenny Sheng, Lei Haley Huang, Jonathon Nixon-Abell, Schuyler Melore, Chyi Wei Chung, Nino F Läubli, Sofia Kapsiani, Xuecong Li, Jingshu Wang, Nancy Zhang, Mahabub Maraj Alam, Alondra S Burguete, Theresa C Swayne, Yanyan Chen, Ya-Cheng Liao, Neil A Shneider, Michele Vendruscolo, Tuomas P J Knowles, Clemens F Kaminski, Francesco Simone Ruggeri, Gabriele S Kaminski Schierle, Peter St George-Hyslop, Alejandro Chavez
Journal: Nat Commun
Doi: https://www.doi.org/10.1038/s41467-025-65178-0
2025/11/21 -
Single-nucleus RNA sequencing reveals GABAergic vulnerability and reactive gliosis driven by loss of TDP-43
Author:
Rashmi Thapa, Navin Adhikari, Sishir Gautam, Mingming Sun, Sierra McOmie, Viyaleta Davydzenka, Derek Smith, Jack Syring, Harlie Kaligis, Jade Marie Kosmicki, Rong Chen, Yun Li
Journal: iScience
Doi: https://www.doi.org/10.1016/j.isci.2025.113745
2025/11/21 -
Tianma-Chuanxiong synergically inhibit glioma by regulating the miR-101/COX-2/AKT signal
Author:
Zhou Xin-yi, Xu Chun-qi, Lai Nian-hong, Hu Ying, Zhang En-xin, Wu Wen-jiang, Zeng Jia-xin, Liu Bo, Zhang Xiao-jun
Journal: Journal of Ethnopharmacology
Doi: https://www.doi.org/10.1016/j.jep.2025.120939
2025/11/20 -
A Novel miniALPK3 Gene Therapy for ALPK3-Associated Cardiomyopathy
Author:
Wei Feng, Julijus Bogomolovas, Abraham Grant Shain, Li Wang, Chao Chen, Mao Ye, Yusu Gu, Xiaohai Zhou, Ju Chen
Journal: Circulation
Doi: https://www.doi.org/10.1161/CIRCULATIONAHA.125.074632
2025/11/19 -
Long-Term Attenuation of Vascular Hyperpermeability in a Hereditary Angioedema Mouse Model by Adenine Base Editing
Author:
Yang Wang, Yuxuan Kong, Yingjie Zhang, Yunjie He, Wei Wang, Yuanbin Lu, Juan Meng, Huijun Yuan
Journal: Allergy
Doi: https://www.doi.org/10.1111/all.70152
2025/11/14 -
Skeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8+ T cell-secreted CCL5
Author:
Mingchong Liu, Yi Han, Jiaming Wang, Yimin Zhu, Yueqi Zhang, Qining Chu, Chensong Yang, Bingdi Chen, Guixin Sun
Journal: eBioMedicine
Doi: https://www.doi.org/10.1016/j.ebiom.2025.106024
2025/11/13