化学遗传-rAAV

化学遗传学是一种用于选择性操控细胞信号传导的技术。它通过基因工程改造细胞膜上的受体，使其仅对特定的外源化学物质产生响应。经过改造的受体在被这些原本惰性的外源分子激活后，能够驱动细胞内源性G蛋白信号通路的传导。DREADDs（Designer Receptors Exclusively Activated by Designer Drugs，即设计性受体仅由设计性药物激活）是目前最常用的化学遗传学受体，并且在神经科学等多个研究领域得到了广泛的应用。

派真生物提供预制的化学遗传学AAV产品，用于化学遗传学实验中特定DREADDs的表达，可以直接、便捷且高效地用于体内实验，并且附带完整的质量检验报告，确保实验的可靠性和重复性。

服务明细

启动子	质粒编号	质粒名称
EF1a	DR031	ssAAV.EF1a- hM3Dq- mCherry- WPRE
	DR032	ssAAV.EF1a- DIO-HA- hM3D(Gq)- IRES- mCitrine
	DR034	ssAAV.EF1a- HA- hM3D(Gq)- mCherry
	DR035	ssAAV.EF1a- hM3D(Gq)- mCherry
	DR036	ssAAV.EF1a- DIO- hM3D(Gq)- mCherry
	DR038	ssAAV.EF1a- DIO- rM3D(Gs)- mCherry
	DR039	ssAAV.EF1a- DIO- hM4D(Gi)- mCherry
	DR0310	ssAAV.EF1a- HA- hM4D(Gi)- mCherry
	DR0311	ssAAV.EF1a-DIO- mCherry
	DR0312	ssAAV.EF1a- dF-HA- KORD- IRES- mCitrine
	DR0313	ssAAV.EF1a-HA-KORD-IRES-mCitrine
	DR0314	ssAAV.EF1a-DIO-GFP
mOXT	DR391	ssAAV.mOXT-hM3Dq-mCherry-WPRE
	DR392	ssAAV.mOXT-DIO-HA-hM3D(Gq)-IRES-mCitrine
	DR393	ssAAV.mOXT-HA-hM3D(Gq)-IRES-mCitrine
	DR394	ssAAV.mOXT-HA-hM3D(Gq)-mCherry
	DR396	ssAAV.mOXT-DIO-hM3D(Gq)-mCherry
	DR398	ssAAV.mOXT-DIO-rM3D(Gs)-mCherry
	DR3912	ssAAV.mOXT-dF-HA-KORD-IRES-mCitrine
	DR3913	ssAAV.mOXT-HA-KORD-IRES-mCitrine
hSyn	DR101	ssAAV.hSyn- hM3Dq-mCherry-WPRE
	DR102	ssAAV.hSyn- DIO- HA- hM3D(Gq)- IRES- mCitrine
	DR103	ssAAV.hSyn- HA- hM3D（Gq)- IRES- mCitrine
	DR104	ssAAV.hSyn- HA- hM3D(Gq)- mCherry
	DR106	ssAAV.hSyn- DIO- hM3D(Gq)- mCherry
	DR108	ssAAV.hSyn-DIO-rM3D(Gs)-mCherry
	DR109	ssAAV.hSyn-DIO-hM4D(Gi)-mCherry
	DR1011	ssAAV.hSyn- DIO- mCherry
	DR1012	ssAAV.hSyn-dF-HA-KORD-IRES-mCitrine
	DR1014	ssAAV.hSyn.DIO.EGFP.WPRE.bGHpA
	DR1015	ssAAV.hSyn.DIO.EGFP.WPRE.SV40pA
CaMKlla	DR131	ssAAV.CaMKlla- hM3Dq- mCherry- WPRE
	DR133	ssAAV.CaMKIIa-HA-hM3D(Gq)-IRES-mCitrine
	DR134	ssAAV.CaMKIIa-HA-hM3D(Gq)-mCherry
	DR135	ssAAV.CaMKlla- hM3D(Gq)- mCherry
	DR136	ssAAV.CaMKlla- DIO- hM3D(Gq)- mCherry
	DR138	ssAAV.CaMKlla- DIO- rM3D(Gs)-mCherry
	DR139	ssAAV.CaMKlla- DIO- hM4D(Gi)-mCherry
	DR1310	ssAAV.CaMKlla- HA- hM4D(Gi)- mCherry