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Viral-mediated knockdown of Atxn2 attenuates TDP-43 pathology and muscle dysfunction in the PFN1C71G ALS mouse model
Author:
Zachary C. E. Hawley, Xueying Li, Dora Bodnar, Yuanzheng Gu, Yi Luo, Daniel Ferretti, Adam Sheehy, Rachelle Driscoll, Maria I. Zavodszky, Shaolong Cao, Isabel Isaza, Luke Jandreski, Yuqing Liu, Thomas Carlile, Shih-Ching Lo, Anna Grimard, Shawn Bourque, Aditya Utturkar, Samantha Desmarais, H. Moore Arnold, Dann Huh, Edward Guilmette & Deborah Y. Kwon
Journal: Acta Neuropathologica Communications
Doi: https://www.doi.org/10.1186/s40478-025-02005-z
2025-05-24 -
Overexpression of LINC00880 promotes colorectal cancer growth
Author:
Ge Gao, Peiwen Xu, Chunyu Yang, Mengyuan Qian, Qingwen Wang, Surui Yao, Yuan Yin, Zehua Bian
Journal: Transl Cancer Res
Doi: https://www.doi.org/10.21037/tcr-2025-54
2025-05-23 -
Cross-species tropism of AAV. CPP. 16 in the respiratory tract and its gene therapies against pulmonary fibrosis and viral infection
Author:
Zhi Yang, Yizheng Yao, Xi Chen, Victoria Madigan, Shanrui Pu, Xianqun Fan, Jun Pu, Fengfeng Bei
Journal: Cell Reports Medicine
Doi: https://www.doi.org/10.1016/j.xcrm.2025.102144
2025-05-22 -
Transcription Factor‐Based Gene Therapy Enables Functional Repair of Rat Following Chronic Ischemic Stroke
Author:
Tao Wang, Xu Wang, Shanggong Liu, Menglei Li, Kaiying Wan, Jiajun Zheng, Kai Liao, Jinyu Wang, Kaiming Zou, Lu Wang, Hao Xu, Wenliang Lei, Gong Chen, Wen Li
Journal: CNS Neuroscience & Therapeutics
Doi: https://www.doi.org/10.1111/cns.70448
2025-05-22 -
Deciphering signaling mechanisms and developmental dynamics in extraembryonic mesoderm specification from hESCs
Author:
Baohua Niu, Da Wang, Yingjie Hu, Yundi Wang, Gaohui Shi, Zhongying Chen, Lifeng Xiang, Chi Zhang, Xuesong Wei, Ruize Kong, Hongzhi Cai, Weizhi Ji, Yu Yin, Tianqing Li & Zongyong Ai
Journal: Cell lineage, Pluripotency, Pluripotent stem cells
Doi: https://www.doi.org/10.1038/s41467-025-59491-x
2025-05-21 -
Engineering novel AAV capsids by global de-targeting and subsequent muscle-specific tropism in mice and NHPs
Author:
Yue Pan, Yujian Zhong, Huan Chen, Youwei Zhang, Zhiyong Dai, Junlin Chen, Keqin Tan, Xiaoqu Chen, Danlan Qiu, Longxiang Sheng, Xinping Tan, Ying Fan, Ye Bu, Zexin Zhou, Zhiming Yang, Rui Duan, Min Guan, Guangping Gao, Huapeng Li
Journal: BioRxiv
Doi: https://www.doi.org/10.1101/2025.05.19.654800
2025-05-19 -
Deficiency of Aging‐Related Gene Chitinase‐Like 4 Impairs Olfactory Epithelium Homeostasis
Author:
Tingting Wu, Weihao Li, Liujing Zhuang, Jinxia Liu, Ping Wang, Ye Gu, Yongliang Liu, Yiqun Yu
Journal: Cell Proliferation
Doi: https://www.doi.org/10.1111/cpr.70055
2025-05-19 -
Conquering the Complexities of AAV Manufacturing: Advances in Efficiency, Scalability, Compliance: CDMOs/CROs are making progress in removing traditional
Author:
Kathy Liszewski
Journal: Genetic Engineering & Biotechnology News
Doi: https://www.doi.org/10.1089/gen.45.05.22
2025-05-13 -
Neural organoids protect engineered heart tissues from glucolipotoxicity by transferring versican in a co-culture system
Author:
Baochen Bai, Jiting Li, Ze Wang, Yuhan Yang, Jieqing He, Gonglie Chen, Yufan Zhang, Yan Qi, Zhongjun Wan, Lin Cai, Run Wang, Kai Wang, Dongyu Zhao, Jingzhong Zhang, Weihua Huang, Ronald X Xu, Mingzhai Sun, Xiao Han, Yan Liu, Donghui Zhang, Wanying Zhu, Jian Liu, Yuxuan Guo
Journal: BioRxiv
Doi: https://www.doi.org/10.1101/2025.05.07.652597
2025-05-12 -
The paraventricular thalamus mediates visceral pain and anxiety-like behaviors via two distinct pathways
Author:
Di Li, Yong-Chang Li, Zheng-Yan Zhu, Fu-Chao Zhang, Qiu-Ying Zhao, Jia-Hui Jiang, Biyu Shen, Yong Tang, Guang-Yin Xu
Journal: Neuron
Doi: https://www.doi.org/10.1016/j.neuron.2025.04.019
2025-05-8 -
An engineered intravitreal injection RPE-tropic AAV vector expressing a bispecific antibody binding VEGF-A and ANG-2 rescues nAMD in animal models and …
Author:
Yuan Cai, Yonghao Gu, Jie Zhang, Ying Zhu, Zhen Ma, Qin He,Yongjia Sun, Mengmeng Yuan, Xiaojun Li, Kai Zhu, Bolong Miao, Jin Zhao, Juan Liu, Min Tang, Dali Tong, Lixia Feng, Ming Ma, Guisheng Zhong, Zilong Qiu, Tian Xue
Journal: Research
Doi: https://www.doi.org/10.34133/research.0717
2025-05-8 -
Downregulation of Dmxl2 disrupts the hearing development in mice
Author:
Tianying Wang, Xuan Zhou, Minglin Chen, Yang Li, Menghua Li, Rong Wang, Rui Guo, Shusheng Gong, Ke Liu
Journal: Neuroscience
2025-05-7