Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease
Nature Biomedical Engineering, 2023. DOI:https://doi.org/10.1038/s41551-023-01007-3 IF=29.234
Mini-dCas13X–mediated RNA editing restores dystrophin expression in a humanized mouse model of Duchenne muscular dystrophy
J Clin Invest, 2023. DOI:https://doi.org/10.1172/JCI162809 IF=19.456
CRISPR-free, programmable RNA pseudouridylation to suppress premature termination codons
Molecular Cell, 2023. DOI:https://doi.org/10.1016/j.molcel.2022.11.011 IF=19.328
TadA reprogramming to generate potent miniature base editors with high precision
Nat Commun, 2023. DOI:https://doi.org/10.1038/s41467-023-36004-2 IF=17.694
Engineered CRISPR-OsCas12f1 and RhCas12f1 with robust activities and expanded target range for genome editing
Nat Commun, 2023. DOI:https://doi.org/10.1038/s41467-023-37829-7 IF=17.694
Develop a Compact RNA Base Editor by Fusing ADAR with Engineered EcCas6e
Advanced Science, 2023. DOI:https://doi.org/10.1002/advs.202206813 IF=17.521
A high-fidelity RNA-targeting Cas13 restores paternal Ube3a expression and improves motor functions in Angelman syndrome mice
Molecular Therapy, 2023. DOI:https://doi.org/10.1016/j.ymthe.2023.02.015 IF=12.91
LAG3+ erythroid progenitor cells inhibit HBsAg seroclearance during finite pegylated interferon treatment through LAG3 and TGF-β
Antiviral Research, 2023. DOI:https://doi.org/10.1016/j.antiviral.2023.105592 IF=10.103
Physical exercise modulates the microglial complement pathway in mice to relieve cortical circuitry deficits induced by mutant human TDP-43
Cell Reports, 2023. DOI:https://doi.org/10.1016/j.celrep.2023.112240 IF=9.995
Distinct reward processing by subregions of the nucleus accumbens
Cell Reports, 2023. DOI:https://doi.org/10.1016/j.celrep.2023.112069 IF=9.995
SARS-CoV-2 SUD2 and Nsp5 Conspire to Boost Apoptosis of Respiratory Epithelial Cells via an Augmented Interaction with the G-Quadruplex of BclII
mBio, 2023. DOI:https://doi.org/10.1128/mbio.03359-22 IF=7.786
Rational design of multivalent biosensor surfaces to enhance viral particle capture
Journal of Materials Chemistry B, 2023. DOI:https://doi.org/10.1039/D2TB02828J IF=7.571
Tunable nanochannel resistive pulse sensing device using a novel multi-module self-assembly
Analytica Chimica Acta, 2023. DOI:https://doi.org/10.1016/j.aca.2023.341035 IF=6.911
Oridonin employs interleukin 1 receptor type 2 to treat noise-induced hearing loss by blocking inner ear inflammation
Biochemical Pharmacology, 2023. DOI:https://doi.org/10.1016/j.bcp.2023.115457 IF=6.1
Intravenous AAV9 administration results in safe and widespread distribution of transgene in the brain of mini-pig
Front Cell Dev Biol, 2023. DOI:https://doi.org/10.3389/fcell.2022.1115348 IF=6.081
Regulation of Satiety by Bdnf-e2-Expressing Neurons through TrkB Activation in Ventromedial Hypothalamus
Biomolecules, 2023. DOI:https://doi.org/10.3390/biom13050822 IF=6.064
GABAergic neurons in the Nucleus Accumbens are involved in the general anesthesia effect of propofol
Molecular Neurobiology, 2023. DOI:https://doi.org/10.21203/rs.3.rs-2723747/v1 IF=5.682
P2X7 receptor-mediated depression-like reactions arising in the mouse medial prefrontal cortex Get access Arrow
Cerebral Cortex, 2023. DOI:https://doi.org/10.1093/cercor/bhad166 IF=4.861
Sexually dimorphic effects of estrogen receptor 2 deletion in the dorsal raphe nucleus on emotional behaviors
Journal of Neuroendocrinology, 2023. DOI:https://doi.org/10.1111/jne.13195 IF=3.87
Engineered self-healing single-cavity microcapsules for pulsatile release of drug delivery
Particuology, 2023. DOI:https://doi.org/10.1016/j.partic.2022.11.015 IF=3.251
Lycorine Protects Motor Neurons Against TDP-43 Proteinopathy in Animal Models with Amyotrophic Lateral Sclerosis
Neurology eJournal, 2023.  DOI:https://doi.org/10.2139/ssrn.4390302
Neurod1 and Ascl1 Convert Human Astrocytes into Neurons in Ex Vivo Culture of Human Brain Tissue
Neurology eJournal, 2023.  DOI:https://doi.org/10.2139/ssrn.4378268
Base editing as a genetic treatment for spinal muscular atrophy
BioRxiv, 2023.  DOI:https://doi.org/10.1101/2023.01.20.524978
Focused ultrasound-mediated brain genome editing
Res Sq, 2023.  DOI:https://doi.org/10.21203/rs.3.rs-2365576/v1
Efficient Modulation of Exon Skipping via Antisense Circular RNAs
Research (Wash D C), 2023.  DOI:https://doi.org/10.34133/research.0045
Reconstruction of the alveolar–capillary barrier in vitro based on a photo-responsive stretchable Janus membrane
Smart Medicine, 2023.  DOI:https://doi.org/10.1002/SMMD.20220035
Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing
in vitro and in vivo
Nature Biotechnology, 2022. DOI:https://doi.org/10.1038/s41587-021-01180-3 IF=68.164
LDL receptor-related protein 1 (LRP1), a novel target for opening the blood-labyrinth barrier (BLB)
Signal Transduction and Targeted Therapy, 2022. DOI: https://doi.org/10.1038%2Fs41392-022-00995-z IF=38.104
Bone morphogenetic protein 4 inhibits pulmonary fibrosis by modulating cellular senescence and mitophagy in lung fibroblasts
European Respiratory Journal, 2022. DOI:https://doi.org/10.1183/13993003.02307-2021 IF=33.795
Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry
Cell Metabolism, 2022. DOI:https://doi.org/10.1016%2Fj.cmet.2022.01.008 IF=31.373
Age-stratified adeno-associated virus serotype 3 neutralizing and total antibody prevalence in hemophilia A patients from India
Journal of Medical Virology, 2022. DOI:https://doi.org/10.1002/jmv.27859 IF=20.693
Rescue of autosomal dominant hearing loss by in vivo delivery of mini dCas13X-derived RNA base editor
Science Translational Medicine, 2022. DOI:https://doi.org/10.1126/scitranslmed.abn0449 IF=19.319
Mettl3-mediated mRNA m6A modification controls postnatal liver development by modulating the transcription factor Hnf4a
Nature Communications, 2022. DOI:DOI:https://doi.org/10.1038/s41467-022-32169-4 IF=17.7
dCas9-VPR-mediated transcriptional activation of functionally equivalent genes for gene therapy
Nature Protocols, 2022. DOI:https://doi.org/10.1038/s41596-021-00666-3 IF=17.021
Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation
Cardiovascular Research, 2022. DOI:https://doi.org/10.1093/cvr/cvac077 IF=10.787
NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry
Science China-Life Sciences, 2022. DOI:https://doi.org/10.1007%2Fs11427-021-1929-y IF=10.372
A broad-spectrum nanobody targeting the C-terminus of the hepatitis B surface antigen for chronic hepatitis B infection therapy
Antiviral Research, 2022. DOI:https://doi.org/10.1016/j.antiviral.2022.105265 IF=10.103
Rational design of AAVrh10-vectored ACE2 functional domain to broadly block the cell entry of SARS-CoV-2 variants
Antiviral Research, 2022. DOI:https://doi.org/10.1016/j.antiviral.2022.105383 IF=10.103
PreS/2-21-Guided siRNA Nanoparticles Target to Inhibit Hepatitis B Virus Infection and Replication
Frontiers in Immunology, 2022. DOI:https://doi.org/10.3389%2Ffimmu.2022.856463 IF=8.786
St13 protects against disordered acinar cell arachidonic acid pathway in chronic pancreatitis
Journal of Translational Medicine, 2022. DOI:https://doi.org/10.1186%2Fs12967-022-03413-8 IF=8.44
Versatile and efficient in vivo genome editing with compact Streptococcus pasteurianus Cas9
Journal of Medicinal Chemistry, 2022. DOI:https://doi.org/10.1016/j.ymthe.2021.06.013 IF=8.039
A Whole-Brain Cell-Type Specific Sparse Neuron Labeling Method and Its Application in a Shank3 Autistic Mouse Model
Frontiers in Cellular Neuroscience, 2022. DOI:https://doi.org/10.1101/2020.03.15.991844 IF=6.147
Optical Activation of the Dorsal Horn of the Thoracic Spinal Cord Prevents Ventricular Arrhythmias in Acute Myocardial Ischemia-Reperfusion Rats
Frontiers in Cardiovascular Medicine, 2022. DOI:https://doi.org/10.3389%2Ffcvm.2022.753959 IF=5.846
Expression Pattern of ALOXE3 in Mouse Brain Suggests Its Relationship with Seizure Susceptibility
Cellular and Molecular Neurobiology, 2022. DOI:https://doi.org/10.1007/s10571-020-00974-4IF=5.046
Anti-HBc IgG Responses Occurring at the Early Phase of Infection Correlate Negatively with HBV Replication in a Mouse Model
viruses, 2022. DOI:https://doi.org/10.3390/v14092011IF=4.911
Development and Application of a Liquid Chromatography Mass Spectrometry Method for Residual Iodixanol Quantification in AAV-Based Gene Therapy Product Development
Human Gene Therapy, 2022. DOI:https://doi.org/10.1089/hum.2021.136 IF=4.793
Liver-Targeted Nanoparticles Facilitate the Bioavailability and Anti-HBV Efficacy of Baicalin In Vitro and In Vivo
Biomedicines, 2022. DOI:https://doi.org/10.3390%2Fbiomedicines10040900 IF=4.757
Compact Cje3Cas9 for Efficient In Vivo Genome Editing and Adenine Base Editing
The CRISPR Journal, 2022. DOI:https://doi.org/10.1089/crispr.2021.0143 IF=4.321
The SARS-CoV-2 rS1-E-PLGA nanovaccine and evaluation of its immune effect in BALB/c mice
European Review for Medical and Pharmacological Sciences, 2022. DOI:10.26355/eurrev_202207_29316 IF=3.784
Sexually dimorphic effects of estrogen receptor 2 deletion in the dorsal raphe nucleus on emotional behaviors
Journal of Neuroendocrinology, 2022. DOI:DOI:10.1111/jne.13195 IF=3.627
Serpina3n is closely associated with fibrotic procession and knockdown ameliorates bleomycin induced pulmonary fibrosis
Biochemical and Biophysical Research Communications, 2022. DOI:https://doi.org/10.1016/j.bbrc.2020.08.094 IF=3.322
Effects of hCG on DA neuronal death of Parkinson’s disease
Biochemical and Biophysical Research Communications, 2022. DOI:https://doi.org/10.1016/j.bbrc.2022.05.089 IF=3.322
Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors.
BioRxiv, 2022.  DOI:https://doi.org/10.1186/s13073-021-00876-0 
A new strategy: identification of specific antibodies for neutralizing epitope on SARS-CoV-2 S protein by LC-MS/MS combined with immune repertoire
Mol Biomed, 2022.  DOI:https://doi.org/10.1186%2Fs43556-022-00085-0 
Efficient Dlx2-mediated astrocyte-to-neuron conversion and inhibition of neuroinflammation by NeuroD1
BioRxiv, 2022.  DOI: https://doi.org/10.1101/2022.07.11.499522
Enhancing NeuroD1 Expression to Convert Lineage-Traced Astrocytes into Neurons
BioRxiv, 2022.  DOI: https://doi.org/10.21203/rs.3.rs-68414/v1
Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge
BioRxiv, 2022.  DOI: https://doi.org/10.1101/2020.12.18.423554
Biomimetic Alveolus-on-a-Chip for SARS-CoV-2 Infection Recapitulation
Research (Wash D C), 2022. DOI:https://doi.org/10.34133%2F2022%2F9819154 
Four doses of the inactivated SARS-CoV-2 vaccine redistribute humoral immune responses away from the Receptor Binding Domain
medRxiv, 2022. DOI:DOI: https://doi.org/10.1101/2022.02.19.22271215
A hippocampal-hypothalamic circuit essential for anxiety-related behavioral avoidance
BioRxiv, 2022.  DOI: https://doi.org/10.1101/2022.01.17.476545
Promoter CAG is more efficient than hepatocyte targeting TBG for transgene expression via rAAV8 in liver tissues.
Rep. 2022. DOI: 10.3892/mmr.2021.12532
Eliminating base -editor -induced genome -wide and transcriptome -wide off-target mutations.
Human Gene Therapy, 2021. DOI: https://doi.org/10.1038/s41556-021-00671-4 IF=20.761
Programmed genome editing by a miniature CRISPR-Cas12f nuclease.
Nature Chemical Biology, 2021. DOI: https://doi.org/10.1038/s41589-021-00868-6.IF=12.587
Human ACE2‑Functionalized Gold “Virus‑Trap” Nanostructures for Accurate Capture of SARS‑CoV‑2 and Single‑Virus SERS Detection.
Nanomicro Lett. 2021. DOI: 10.1007/s40820-021-00620-8 IF=12.2645
In vivo genome editing in mouse restores dystrophin expression in Duchenne muscular dystrophy patient muscle fibers
Genome Medicine, 2021. DOI:https://doi.org/10.1186/s13073-021-00876-0 IF=10.675
The Parkinson’s disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release.
J Med Chem. 2021. DOI: 10.1073/pnas.2006476118IF=9.412
CRISPR/Cas9 -Mediated Gene Correction in Newborn Rabbits with Hereditary Tyrosinemia Type I.
Molecular Therapy, 2021. DOI: https://doi.org/10.1016/j.ymthe.2020.11.023 IF=8.986
Versatile and efficient in vivo genome editing with compact Streptococcus pasteurianus Cas9, Molecular Therapy.
J Med Chem. 2021. DOI: https:// doi.org/10.1016/j.ymthe.2021.06.013IF=8.986
The immunodominant and neutralization linear epitopes for SARS-CoV-2.
Cell Reports, 2021. DOI: https://doi.org/10.1016/j.celrep.2020.108666.IF=8.109
Hepatocyte-targeting and microenvironmentally responsive glycolipid-like polymer micelles for gene therapy of hepatitis B.
Molecular Therapy – Nucleic Acids 2021.DOI: https://doi.org/10.1016/j.omtn.2021.02.013 IF=7.032
Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models.
J Med Chem. 2021. DOI: 10.1021/acs.jmedchem.0c01929 IF=6.205
Differential development and electrophysiological activity in cultured cortical neurons from the mouse and cynomolgus monkey.
Human Gene Therapy, 2021. DOI: 10.4103/1673-5374.313056. IF=5.135
Prevalence of Adeno-Associated Virus 3 Capsid Binding and Neutralizing Antibodies in Healthy and Hemophilia B Individuals from India.
Human Gene Therapy, 2021. DOI: https://doi.org/10.1089/hum.2020.258IF=4.51
Use of CRISPR/Cas9-mediated disruption of CNS cell type genes to profile transduction of AAV by neonatal intracerebroventricular delivery in mice.
Neural Regen Res 2021. DOI: https://doi.org/10.1038/s41434-021-00223-3 IF=4.128
SCD Inhibition Protects from α-Synuclein- Induced Neurotoxicity But Is Toxic to Early Neuron Cultures.
eNeuro, 2021. DOI: https://doi.org/10.1523/ENEURO.0166-21.2021IF=3.317
Lineage tracing of direct astrocyte-to-neuron conversion in the mouse cortex.
Neural Regen Res 2021. DOI: 10.4103/1673-5374.295925 IF=3.171
Development of a one-step RT-ddPCR method to determine the expression and potency of AAV vectors.
Human Gene Therapy, 2021. DOI: https://doi.org/10.1016/j.omtm.2021.05.003.
Synthetic immunomodulation with a CRISPR super repressor in vivo[J].
Nature Cell Biology, 2020. DOI: 10.1038/s41556-020-0563-3 IF=20.042
JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency. nature communications 2020.
DOI: https://doi.org/10.1038/s41467-020-18900-z IF=12.121
MicroRNA-20b Promotes Cardiac Hypertrophy by the Inhibition of Mitofusin 2-Mediated Inter-organelle Ca 2+ Cross-Talk[J].
Molecular therapy. Nucleic acids, 2020. DOI: https://doi.org/10.1016/j.omtn.2020.01.017 IF=7.032
Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV2 Infection in Mouse Models. J Med Chem 2020.
J Med Chem 2020. DOI: 10.1021/acs.jmedchem.0c01929 IF=6.205
Temperature dependence of the SARS-CoV-2 affinity to human ACE2 determines COVID-19 progression and clinical outcome.
CSBJ 2020. DOI: https://doi.org/10.1016/j.csbj.2020.12.005IF=6.018
Adeno Associated Virus D Sequence Mediated Suppression of Expression of a Human Major Histocompatibility Class II Gene : Implications in the Development of Adeno Associated Virus Vectors for Modulating Humoral Immune Response[J].
Molecular therapy. Nucleic acids, 2020. DOI: 10.1089/hum.2020.018 IF=4.273
Enhanced Transduction of Human Hematopoietic Stem Cells by AAV6 Vector Implications in Gene Therapy and Genome Editing[J].
Human Gene Therapy, 2020. DOI: 10.1016/j.omtn.2020.03.009 IF=4.273
A Whole-Brain Cell-Type Specific Sparse Neuron Labeling Method and Its Application in a Shank3 Autistic Mouse Model[J].
Front Cell Neurosci, 2020. DOI: 10.3389/fncel.2020.00145 IF=3.921
Serpina3n is closely associated with fibrotic procession and knockdown ameliorates bleomycin induced pulmonary fibrosis.
Biochem Biophys Res Commun. 2020. DOI: 10.1016/j.bbrc.2020.08.094IF=3.027
Neurobiology-Expression Pattern of ALOXE3 in Mouse Brain Suggests Its Relationship with Seizure Susceptibility,
Cellular and Molecular,2020. DOI: https://doi.org/10.1007/s10571-020-00974-4IF=1.72
Comment on Rapid and efficient in vivo astrocyte -to- neuron conversion with regional identity and connectivity.
2020. bioRxiv DOI: https://doi.org/10.1101/2020.09.02.279273
The immunodominant and neutralization linear epitopes for SARS-CoV-2.
Cell Reports, 2020. DOI: 10.1016/j.celrep.2020.108666
Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice[J].
Nature Neuroscience, 2019. DOI: 10.1038/s41593-019-0445-9 IF=28.771
Divergent engagements between adenoassociatedviruses with their cellular receptor AAVR[J].
Nature Communications, 2019. DOI: 10.1038/s41467-019-11668-x IF=17.694
MiR-592 functions as a tumor suppressor in acute myeloid leukemia by targeting ROCK1 and predicts patients’ prognosis[J].
EUR REV MED PHARMACO, 2019. DOI:10.26355/eurrev_201902_17120 IF=3.784
Intravascular Injections of Adeno associated Viral Vector Serotypes rh10 and PHP.B Transduce Murine Sciatic Nerve Axons[J].
Neuroscience Letter, 2019. DOI: 10.1016/j.neulet.2019.05.010IF=3.197
Intravenous injection of AAV-PHP.eB across the blood brain barrier in the adult mouse for central nervous system gene therapy[J].
Oncology and Translational Medicine, 2019.DOI:10.1007/s10330-018-0313-3